Antipsychotic-induced hyperprolactinemia (>29ng/ml in women) is associated with relevant side-effects.

We describe the case of two women aged 50 and 54years, respectively, diagnosed with schizophrenia who were receiving outpatient treatment with paliperidone depot 100mg/month and risperidone depot 50mg/2weeks, respectively and complained of oligoamenorrhoea and amenorrhoea for at least 6months.

Routine blood tests showed hyperprolactinemia of 203.5ng/ml and 306.2ng/ml, respectively. The patients were evaluated by the Endocrinology unit and an MRI was performed discarding the presence of any primary brain condition. Both patients were switched to LAI aripiprazole due to its partial agonism of D2-brain receptors. At the time of switching both patients were stable in terms of psychopathology.

Changes in prolactin levels 3months after switching are shown in the Fig. 1. Two months after switching, both patients regained cyclic menstrual function. After 6months, they still showed psycopathological stability.

Several studies have described an improvement of drug-induced hyperprolactinemia after switching to or adding oral aripiprazole. In these two cases, the normalization of prolactin levels and the resolution of oligoamenorrhoea/amenorrhoea were observed as soon as 2–3months after switching to LAI aripiprazole. These findings suggest that switching to LAI aripiprazole may be an effective alternative for managing antipsychotic-induced hyperprolactinemia.