Pharmacokinetic changes of norfloxacin based on expression of MRP2 after acute exposure to high altitude at 4300 m - 25/04/17
, Wenbin Li a, Tao Yang c, Chang Wang a, Hui Lu a, Anpeng Zhao a, Juanhong Zhang a, b, Zhengping Jia a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Background |
This study was to investigate the influence of physiological changes and the expression of MRP2 efflux transporter on the pharmacokinetics of norfloxacin after acute exposure to high altitude 4300m.
Methods and Results |
The rats were randomly divided into high altitude group and plain group. Blood gas and biochemical analysis showed that the physiological parameters significantly changed at high altitude. The mRNA and protein expression of MRP2 in high altitude group were higher than plain group in rat small intestine and kidney, while was reduced in rat liver. The AUC, Ka and Cmax of norfloxacin were significantly reduced in high altitude group (p<0.05). However, the MRT, CL, t1/2 and Vd were significantly increased (p<0.05).
Conclusions |
These results indicate that physiological indicators and expression levels of drug transporters MRP2 are changed in responded to high altitude, to severely affect norfloxacin pharmacokinetics. These changes may provide basis and new ideas to adjust the dosage and administration, so as to promote rational drug use in the high altitude.
Le texte complet de cet article est disponible en PDF.Keywords : High altitude, Norfloxacin, Physiological changes, MRP2 expression changes, Pharmacokinetics
Plan
Vol 89
P. 1078-1085 - mai 2017 Retour au numéro
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