Genetic classification helps with precise sirolimus treatment in slow-flow vascular malformations: A prospective cohort study - 08/05/25

Doi : 10.1016/j.jaad.2025.04.013

Hongyuan Liu, MD, PhD ^a, Yuxi Chen, MD ^a, Xuanfeng Chen, MD ^a, Shih-Jen Chang, MD, PhD ^a, Yamin Rao, MD, PhD ^b, Xi Yang, PhD ^a, Li Hu, MD, PhD ^a, Zian Xu, PhD ^a, Hao Gu, PhD ^a, Yajing Qiu, PhD ^a, Chen Hua, MD, PhD ^a, Hui Chen, MD, PhD ^a,^⁎ , Xiaoxi Lin, MD, PhD ^a,^⁎
^a Departments of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
^b Department of Pathology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

^∗Correspondence to: Xiaoxi Lin, MD, PhD, and Hui Chen, MD, PhD, Departments of Plastic and Reconstructive Surgery and Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, ChinaDepartments of Plastic and Reconstructive Surgery and Laser and Aesthetic MedicineShanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine639 Zhizaoju RdShanghai200011China

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Thursday 08 May 2025
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Key words : genomics, PIK3CA, sirolimus, targeted therapy, TEK, vascular malformation

	Drs Liu, Y. Chen, X. Chen, and Chang contributed equally in this article and should be considered as co-first authors.
	Funding sources: This study was supported by the Clinical Research Program of Shanghai Municipal Health Commission (202040433), the Clinical Research Plan of Shanghai Hospital Development Center (SHDC2020CR2036B), Shanghai Municipal Key Clinical Specialty (shslczdzk00901), the Cross Research Fund Project of the Shanghai Ninth People's Hospital (JYJC202118), YBKA202209/Project of Biobank from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, and General Program of National Natural Science Foundation of China (82472577).
	Patient consent: Consent for the publication of recognizable patient photographs or other identifiable material was obtained by the authors and included at the time of article submission to the journal stating that all patients gave consent with the understanding that this information may be publicly available.
	IRB approval status: Reviewed and approved by Shanghai Ninth People's Hospital IRB; approval SH9H-2019-T164-1 and SH9H-2020-TK385-1.

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Genetic classification helps with precise sirolimus treatment in slow-flow vascular malformations: A prospective cohort study - 08/05/25

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