Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea - 18/04/17
Abstract |
Background |
Associations between vitiligo and thyroid diseases have been reported repeatedly.
Objective |
We investigated the associations between vitiligo and overt autoimmune thyroid diseases and thyroid cancer using the Korean National Health Insurance claims database.
Methods |
We defined patients with vitiligo as those whose records showed ≥4 physician contacts between 2009 and 2013 in which vitiligo was the principal diagnosis. We also established an age- and sex-matched control group without vitiligo (2 per 1 vitiligo patient). The outcomes of interest were concurrent Graves disease and Hashimoto thyroiditis (the patients were taking relevant thyroid medications) and thyroid cancer.
Results |
The study enrolled 73,336 vitiligo patients and 146,672 controls. Patients with vitiligo were at increased risks of Graves disease (odds ratio [OR] 2.610 [95% confidence interval {CI} 2.319-02.938]), Hashimoto thyroiditis (OR 1.609 [95% CI 1.437-1.802]), and thyroid cancer (OR 1.127 [95% CI 1.022-1.242]), compared with the controls. The associations were consistently stronger in males and younger patients.
Limitations |
Individual clinical information was not available, and the homogeneous population may limit the generalizability of the results.
Conclusion |
Vitiligo was significantly associated with overt autoimmune thyroid diseases and overt thyroid cancer.
Le texte complet de cet article est disponible en PDF.Key words : autoimmune thyroiditis, Graves disease, Hashimoto thyroiditis, hyperthyroidism, hypothyroidism, thyroid cancer, vitiligo
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
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| Drs Bae and Lee contributed equally to this article. |
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| Reprints not available from the authors. |
Vol 76 - N° 5
P. 871-878 - mai 2017 Retour au numéro
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