A meta-analysis of neurocognition in youth with familial high risk for bipolar disorder - 01/08/17
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Abstract |
Objective |
Neuropsychological impairment, including deficits in social cognition is evident in subjects at genetic high-risk for psychosis. However, findings in youth at genetic risk to bipolar disorder (BP) have been suggested to be less supportive of premorbid deficits. We aimed to conduct a meta-analysis of cognitive deficits in youth with familiar risk for bipolar disorder (FHR-BD).
Methods |
A novel meta-analysis of FHR-BD (mean age 10–25), including 18 studies (786 offsprings/siblings of patients with BD and 794 healthy controls), was conducted.
Results |
Both general cognition (d=0.29, CI=0.15–0.44) and social cognition (d=0.23, CI=0–0.45) were impaired in FHR-BD. In comparison to controls, FHR-BD had significant deficits in several cognitive domains, including visual memory (d=0.35), verbal memory (d=0.21), processing speed (d=0.26) and sustained attention (d=0.36). There was no significant difference between FHR-BD and controls in planning and working memory.
Conclusions |
Cognitive deficits are evident in individuals who are at genetic high-risk for developing BD. Neurodevelopmental abnormalities are likely playing a role not only in schizophrenia but also in BD.
Le texte complet de cet article est disponible en PDF.Keywords : Bipolar disorder, High-risk, Familial, Cognition
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Vol 44
P. 17-23 - juillet 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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