Background: Preoperative images such as computed tomography scans or magnetic resonance imaging contain lots of valuable information that are not easily available for surgeons during an operation. To help the clinicians better target the structures of interest during an intervention, many registration methods that align preoperative images onto the intraoperative view of the organs have been developed. For important organ deformation, biomechanically-based registration has proven to be a method of choice.

Method: Using an existing biomechanically-based registration algorithm for laparoscopic liver surgery we investigate in this paper the influence of the heterogeneity of the liver on the registration result.

Results: No statistical difference in the results was found between the registration performed with the homogeneous model and the one carried out with the heterogeneous model.

Conclusion: As the use of an heterogeneous model does not improve significantly the registration result and increase the computation time we recommend to perform the type of registration task described in the paper with a simplified homogeneous model.