Molecular mechanisms of anticancer effects of Glucosamine - 14/11/17

Doi : 10.1016/j.biopha.2017.08.122

Fatemeh Zahedipour ^a,^{^{1
These authors contribute equally to this work.}} , Razieh Dalirfardouei ^b,^{^{1
These authors contribute equally to this work.}} , Gholamreza Karimi ^c , Khadijeh Jamialahmadi ^d,^b,^⁎
^a Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
^b Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
^c Pharmaceutical Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
^d Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

^⁎Corresponding author at: Department of Medical Biotechnology, School of Medicine, Pardis Campus, Azadi Square, Mashhad, P.O. Box, 8594−917794, Iran.Department of Medical BiotechnologySchool of MedicineMashhad University of Medical SciencesMashhadIran

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Abstract

Glucosamine is an amino sugar that is produced naturally in human body. It is an essential carbohydrate component of many cellular glycoproteins, glycolipids, and glycosaminoglycans (GAGs). This popular over-the-counter supplement is also found in the exoskeleton of crustaceans. Glucosamine and its derivatives have a long history in medicine for inflammatory conditions specially to relieve arthritis. This dietary supplement has numerous biological and pharmacological properties, including anti-inflammatory, antioxidant, anti-aging, anti-fibrotic, neuroprotective and cardioprotective activities. Many studies have shown that glucosamine has anti-cancer activity through influence on biological pathways involved in cell death, apoptosis, cell proliferation, and angiogenesis. Accordingly, this comprehensive review summarizes anti-cancer molecular mechanisms of glucosamine in details.

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Keywords : Apoptosis, Autophagy, Glucosamine, Inflammation, Molecular signaling

Plan

Introduction

Main molecular mechanisms

Glucosamine alters the uracil and adenine nucleotide contents

Glucosamine damages the structure and function of plasma and cell membrane compartment

Glucosamine induces autophagic cell death

Glucosamine inhibits ubiquitin proteasome pathway

Inhibition of STAT3 signaling pathway

Inhibition of p70S6K

Inhibition of HIF-1 transcription factor

Other mechanisms

Antioxidant activity

Immunostimulating and anti-inflammatory activities

Anti-angiogenic activity

Inhibitory effect on matrix metalloproteinases expression

Targeting activity in drug targeted therapy

Conclusion

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Vol 95

P. 1051-1058 - novembre 2017 Retour au numéro

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Molecular mechanisms of anticancer effects of Glucosamine - 14/11/17

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