IL-1β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1 - 14/11/17
, Qiliang Zhou a, ⁎ , Shijie Chen c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Nowadays, the role of miRNA in tumorigenesis has been largely reported. It was found that miR-506 might be associated with tumorigenesis of various cancers. The present study was aimed to investigate the character of miR-506 and some related factors in human osteosarcoma (OS) carcinogenesis. The expression level of miR-506 was downregulated in OS compared with the normal control group by RT-PCR, both in vivo and in vitro. In addition, IL-1β stimulation decreased the expression of miR-506. MiR-506 interfered with JAG1 gene transcription throughmiR-506 binding to the 3′-UTR region of JAG1 gene. Further siRNA strategy suggested that IL-1β may regulate miR-506 level via NF-κB, and then alter the JAG1 expression. Besides, the suppression of JAG1 by miR-506 inhibited OS cell proliferation. Taken together, our data indicate a process of NF-κB-induced miR-506 suppression and JAG1 upregulation upon IL-1β induction, which can be regarded as a new pathway for modulating cell proliferation via miR-506. It may be of clinical value in treating OS in the future.
Le texte complet de cet article est disponible en PDF.Keywords : IL-1β, NF-κB, miR-506, JAG1, Osteosarcoma
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Vol 95
P. 1147-1155 - novembre 2017 Retour au numéro
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