Inhibition of hemangioma growth using polymer–lipid hybrid nanoparticles for delivery of rapamycin - 14/11/17
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Graphical abstract |
Highlights |
• | Rapamycin-loaded polymer–lipid hybrid nanoparticles (Rapamycin-PLNPs) could show sustained release of rapamycin. |
• | Rapamycin-PLNPs achieved superior therapeutic efficacy over rapamycin in the treatment of infantile hemangiomas. |
• | Rapamycin-PLNPs significantly reduced the frequency of administration of rapamycin. |
Abstract |
Although infantile hemangiomas is benign, its rapid growth may induce serious complications. However, only one drug Hemangeol™ has been approved by US Food and Drug Administration (FDA) to treat infantile hemangiomas. Thus it is necessary to develop novel alternative drugs to treat infantile hemangiomas. Rapamycin is a well-know potent antiangiogenic agent, whereas the daily oral administration of rapamycin exerts undesired metabolic effects due to its inhibition of mechanistic target of rapamycin (mTOR) which is critical in cell metabolism. We hereby developed rapamycin-loaded polymer–lipid hybrid nanoparticles (Rapamycin-PLNPs) as a local controlled release system to realize local and sustained release of rapamycin, aiming to reduce the side effects and frequency of administration of rapamycin. Rapamycin-PLNPs are of a small size (129.1nm), desired drug encapsulation efficiency (63.7%), and sustained drug release for 5 days. Rapamycin-PLNPs were shown to be able to effectively bind to hemangioma endothelia cells (HemECs), induce significant proliferation inhibition and reduce expression of angiogenesis factors in HemECs. The therapeutic effect of Rapamycin-PLNPs against infantile hemangioma in vivo was superior to rapamycin, as reflected by reduced hemangioma volume, weight and microvessel density. Taken together, Rapamycin-PLNPs represent a very promising local approach in the treatment of infantile hemangiomas.
Le texte complet de cet article est disponible en PDF.Keywords : Biomaterials, Rapamycin, Sustained release, Nanoparticles, Hemangioma
Abbreviations : bFGF, CCK-8, DSPE-PEG2000, DSPE-PEG2000-Mal, ECM, EE, EGM-2, ELISA, FBS, FDA, HemECs, HPLC, HUVECs, MVD, PLGA, PTA, Rapamycin-PLNPs, TEM, VEGF-A
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Vol 95
P. 875-884 - novembre 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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