Mesoporous silica and titania are biocompatible materials and could be used as carriers for various drugs due to their excellent hosting capacity. Here, we report studies on the preparation of oxytetracycline delivery systems containing various mesostructured silica–titania SBA-15–type supports with up to 30 mol % titania to establish the influence of structural, textural, and support composition on the oxytetracycline release profile. The antibiotic was loaded into the support mesochannels by the incipient wetness impregnation method. The drug delivery profiles obtained in phosphate-buffered saline showed that the increase in titania content in the mesoporous support slowed down the release kinetics. The oxytetracycline-loaded materials demonstrated good antimicrobial activity against Staphylococcus aureus ATCC 25923 strain.