Prevalence of autoantibodies in the course of Gaucher disease type 1: A multicenter study comparing Gaucher disease patients to healthy subjects - 23/12/17
, Nesma Bensalah c, Guillaume Penaranda d, Nathalie Bardin c, Nadia Belmatoug e, Agathe Masseau f, Christian Rose g, Olivier Lidove h, Fabrice Camou i, François Maillot j, Vanessa Leguy k, Nadine Magy-Bertrand l, Isabelle Marie m, Patrick Cherin n, Monia Bengherbia e, Sebastian Carballo b, José Boucraut c, Jacques Serratrice b, Marc Berger o, Denis Verrot aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objectives |
Type 1 Gaucher disease may be related to the presence of autoantibodies. Their clinical significance is questioned.
Primary endpoint was to compare the prevalence of autoantibodies in type 1 Gaucher disease patients with healthy subjects, seeking correlations with autoimmune characteristics. Secondary endpoints were to determine whether patients with autoantibodies reported autoimmunity-related symptoms and if genotype, splenectomy or treatment influenced autoantibodies presence.
Methods |
Type 1 Gaucher disease patients and healthy volunteers were included in this national multicenter exploratory study. Autoantibodies presence was compared in both groups and assessed regarding to genotype, splenectomy, Gaucher disease treatment and autoimmunity-related symptoms.
Results |
Twenty healthy subjects and 40 type 1 Gaucher disease patients were included. Of the studied group: 15 patients undergone splenectomy, 37 were treated either with enzyme replacement therapy (34) or with substrate reduction therapy (3), 25 were homozygous/heterozygous for the N370S mutation.
In type 1 Gaucher disease group (studied group), 52% had positive autoantibodies versus 26% in control group. Antiphospholipid antibodies were more frequent in the studied group (30% vs. 5%), but without correlation to thrombosis, osteonecrosis or bone infarcts. In the studied group, antinuclear antibodies were more frequent (25% vs. 16%). None of the patients with autoantibodies had clinical manifestations of autoimmune diseases. Autoantibodies were not correlated with treatment, genotype, or splenectomy, except for anticardiolipid, more frequent in splenectomized patients.
Conclusions |
In type 1 Gaucher disease, autoantibodies were more frequent compared to a healthy population. However, they were not associated with an increased prevalence of clinical active autoimmune diseases.
Le texte complet de cet article est disponible en PDF.Keywords : Gaucher disease, Auto immunity, Antibodies, Antinuclear, Antiphospholipid
Plan
Vol 85 - N° 1
P. 71-77 - janvier 2018 Retour au numéro
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