A meta-analysis of nevus-associated melanoma: Prevalence and practical implications - 27/12/17
Abstract |
The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case–control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P < .001; I2 = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference –0.39 mm; 95% CI –0.60 to –0.18; P = .0003; I2 = 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; P = .24; I2 = 98%).
Le texte complet de cet article est disponible en PDF.Key words : dysplastic nevus, melanoma, meta-analysis, nevus-associated, prevalence, thickness
Abbreviations used : CI, DNM, HR, NAM, RR
Plan
Funding sources: Supported by the Italian Ministry of Health (project code: NET-2011-02347213). |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 77 - N° 5
P. 938 - novembre 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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