Alleviation of ginsenoside Rg1 on hematopoietic homeostasis defects caused by lead-acetate - 31/12/17
, Yue Zhou b, 1, Jun Liu c, Cheng-Peng Li c, Dao-Yong Jia c, Meng-Si Zhang c, Ya-Ping Wang c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 8 |
| Iconographies | 7 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
The hematopoietic system is one of the potential targets of lead intoxication. Recognition of the lead-related deleterious outcomes promotes us to explore the potential therapeutic intervention. Here, we show that ginsenoside Rg1 (Rg1), extracted from the Chinese herb Panax ginseng, remarkably ameliorates the lead acetate-caused hematological index distortion as well as advanced hematopoietic stem cells (HSCs) aging and aging associated inflammation response. Specifically, Rg1 administration alleviated the increment of aging associated p53-p21-Rb signaling in aged HSCs induced by lead acetate. It also led a reduction of the lead acetate-induced increased inflammation level in blood plasma, which also partly contribute the aged HSCs rejuvenation. In conclusion, our results indicate that ginsenoside Rg1 therapeutically alleviated the essential blood deficits and advanced HSCs aging by lead acetate exposure, by which it could be viewed as a potential candidate for lead acetate-caused blood toxicity treatment.
Le texte complet de cet article est disponible en PDF.Keywords : Ginsenoside rg1, Lead acetate, Hematopoietic disorders, HSCs senescence, Anti-aging
Plan
Vol 97
P. 1204-1211 - janvier 2018 Retour au numéro
Article précédent
- Alterations of biomechanics in cancer and normal cells induced by doxorubicin
- Kaja Fraczkowska, Marcin Bacia, Magda Przybyło, Dominik Drabik, Aleksandra Kaczorowska, Justyna Rybka, Ewa Stefanko, Slawomir Drobczynski, Jan Masajada, Halina Podbielska, Tomasz Wrobel, Marta Kopaczynska
- Evaluation of anti-urolithiatic and diuretic activities of watermelon (Citrullus lanatus) using in vivo and in vitro experiments
- Waqar Ahmed Siddiqui, Muhammad Shahzad, Arham Shabbir, Ali Ahmad
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?