MicroRNA-373 facilitates HSV-1 replication through suppression of type I IFN response by targeting IRF1 - 31/12/17
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Abstract |
Herpes simplex virus type 1 (HSV-1) had led to kinds of clinical disorders and became an important cause of morbidity and mortality worldwide, such as herpetic gingivostomatitis in children. Previous studies reported that HSV-1 infection is common and has evolved a variety of mechanisms to evade the immune system, such as dysregulation of miRNAs. However, reports concerning the role of miRNA in HSV-1infection are limited. Here, we report that a host microRNA, miR-373, was significantly upregulated by HSV-1 infection in Hela cells and patients with herpetic gingivostomatitis and it facilitated HSV-1 replication in vitro. Subsequently, we demonstrated that miR-373 was a negative regulator of IFN-I response by directly targeting IRF1, resulting in the suppression of interferon stimulated gene (ISG) expression and enhancement of HSV-1 infection. Taken together, our findings provide new evidence of which HSV-1 hijacks the host miRNAs to promote its replication by negatively regulating the production of type I IFN and suggest a novel potential anti-HSV-1 therapeutic target.
Le texte complet de cet article est disponible en PDF.Keywords : HSV-1 replication, miR-373, IRF1, Type I IFN
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Vol 97
P. 1409-1416 - janvier 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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