Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells - 31/12/17
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objective |
To examine whether curcumin has protective effect on insulin resistance induced by bisphenol A (BPA) in LO2 cells and whether this effect was mediated by inhibiting the inflammatory mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) pathways.
Methods |
LO2 cells were stimulated with BPA in the presence or absence of curcumin for 5 days. Glucose consumption, activation of insulin signaling, MAPKs and NF-κB pathways, levels of inflammatory cytokines and MDA production were analyzed.
Results |
Curcumin prevented BPA-induced reduction of glucose consumption and suppression of insulin signaling pathway, indicating curcumin alleviated BPA-triggered insulin resistance in LO2 cells. mRNA and proteins levels of TNF-α and IL-6, as well as MDA level in LO2 cells treated with BPA were decreased by curcumin. Furthermore, curcumin downregulated the activation of p38, JNK, and NF-κB pathways upon stimulation with BPA. Inhibition of JNK pathway, but not p38 nor NF-κB pathway, improved glucose consumption and insulin signaling in BPA-treated LO2 cells.
Conclusion |
Curcumin inhibits BPA-induced insulin resistance by suppressing JNK pathway.
Le texte complet de cet article est disponible en PDF.Keywords : Curcumin, Bisphenol A, Insulin resistance, Inflammation, JNK pathway
Plan
Vol 97
P. 1538-1543 - janvier 2018 Retour au numéro
Article précédent
- Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats
- Md. Shamsir Alam, Abdul Ahad, Lubna Abidin, Mohd. Aqil, Showkat Rasool Mir, Mohd Mujeeb
- Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms
- Nanda Gamad, Salma Malik, Kapil Suchal, Swati Vasisht, Ameesha Tomar, Sudheer Arava, Dharamvir Singh Arya, Jagriti Bhatia
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?