Gastrodin reduces IL-1β-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo - 31/12/17

Doi : 10.1016/j.biopha.2017.10.067

Jian Chen ^a,^{^{1
Jian Chen and Yun-Tao Gu contribute equally to this work and should be considered as co-first authors.}}, Yun-Tao Gu ^a,^{^{1
Jian Chen and Yun-Tao Gu contribute equally to this work and should be considered as co-first authors.}}, Jun-Jun Xie ^b, Cong-Cong Wu ^a, Jun Xuan ^a, Wei-Jun Guo ^a, Ying-Zhao Yan ^a, Long Chen ^a, Yao-Sen Wu ^a, Xiao-Lei Zhang ^a, Jian Xiao ^b,^⁎ , Xiang-Yang Wang ^a,^⁎
^a Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, People's Republic of China
^b School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China

^⁎Corresponding authors at: Department of Spinal Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang Spinal Center, Wenzhou, 325027, People's Republic of China.Department of Spinal SurgerySecond Affiliated Hospital of Wenzhou Medical UniversityZhejiang Spinal CenterWenzhou325027People's Republic of China

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Abstract

Therapeutics for osteoarthritis (OA) are intended to restore chondrocyte function and inhibit cell apoptosis. Previous studies have shown that gastrodin had anti-apoptotic and anti- inflammatory effects. However, little is known about whether gastrodin has protective effects against the processes of OA. We studied the potential effects of gastrodin on chondrocytes and the underlying mechanisms. Our results showed that gastrodin could prevent chondrocyte apoptosis induced by IL-1β. Additionally, gastrodin suppressed the nuclear factor kappa B (NF-κB) pathway, decreased the release of inflammatory mediators (IL-6, TNF-α), and reduced matrix catabolism in IL-1β-treated chondrocytes. Furthermore, gastrodin ameliorated rat cartilage degeneration in an OA model of knee joints in vivo, suggesting its potential as a candidate therapeutic for OA.

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Keywords : Gastrodin, NF-κB, Inflammation, Apoptosis, Osteoarthritis

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Vol 97

P. 642-651 - janvier 2018 Retour au numéro

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Gastrodin reduces IL-1β-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo - 31/12/17

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