Psychotropic agent thioridazine elicits potent in vitro and in vivo anti-melanoma effects - 31/12/17

Doi : 10.1016/j.biopha.2017.11.012

Xiaoshuang Jiang ^a,^{^{1
Those authors contributed equally to this work.}}, Zhixing Chen ^b,^{^{1
Those authors contributed equally to this work.}}, Guobo Shen ^c, Yong Jiang ^d, Liangjun Wu ^b, Xue Li ^c, Guoping Wang ^c,^⁎ , Tao Yin ^c,^⁎
^a Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, PR China
^b Department of Plastic Surgery, West China Hospital, Chengdu 610041, PR China
^c Department of Oncology, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, PR China
^d Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, PR China

^⁎Corresponding author at: Department of Oncology, Cancer Center，West China Hospital, Sichuan University, People's South Road three section 17 number, Chengdu 610041, China.Department of OncologyCancer CenterWest China HospitalSichuan University and Collaborative Innovation CenterChengdu610041PR China

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Abstract

Psychotropic agents have been shown anti-tumor potential in recent years. In the present study, our in vitro pharmacological data indicated that thioridazine inhibited melanoma cells proliferation. The growth-arresting effect of thioridazine was accompanied by autophagy induction, as shown by immunoblotting of increased LC3II. Besides, certain apoptotic events had also occurred after thioridazine exposure. The in vivo anti-melanoma effect of thioridazine was confirmed by showing that intraperitoneally injection of thioriazine remarkably retarded tumor growth and reduced tumor vasculature. Our results imply that thioridazine might be an available therapeutic agent for melanoma patients with no better options.

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Keywords : Thioridazine, Melanoma, Autophagy, Apoptosis, Angiogenesis

Plan

Introduction

Materials and methods

Cells culture and agents

Measurement of viability

Apoptosis examination

Western blotting analysis

Tumor challenge and therapy

Thioridazine inhibited proliferation of melanoma cells

Thioridazine induced autophagy

Thioridazine induced apoptosis and altered the PD-1 expression

Thioridazine retarded tumor growth in vivo

Thioridazine inhibited angiogenesis in melanoma microenvironment

Discussion

Conflicts of interest

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Vol 97

P. 833-837 - janvier 2018 Retour au numéro

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Psychotropic agent thioridazine elicits potent in vitro and in vivo anti-melanoma effects - 31/12/17

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