Relationship between uric acid and blood pressure levels in the area of Blida (Algeria) - 05/01/18
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Résumé |
Purpose |
The aim of the present study was to assess the predictive role of uric acid (UA) for the incidence of coronary artery disease (CAD) in essential hypertensive (EH) patients.
Methods |
We followed up 2226 essential hypertensives (mean age 58.4years, 1675 males) for a mean period of 3years. Data were collected with individual questionnaire. All subjects had preserved renal function. Clinical and biological assessments were performed in order to detect UA and kidney function. At least one annual visit and at baseline underwent echocardiographic study and blood sampling.
Results |
Women had lower UA (71.1%<6mg/dL, compared to 28.9%>6mg/dL). Mean value of UA was 7.2mg/dL among males (vs 4.7mg/dL among females; P: 0.01). Only age and UA remain significant in multivariate analysis with all elements under investigation (respectively P=0.01 and P=0.04). We found that UA plasmatic levels are associated with sex (multivariate analysis: P<0.04), BMI (P=0.02), renal function (P=0.01). The incidence of CAD was 4.5%. Hypertensives who developed CAD (n=65) compared to those without CAD at follow-up (n=2161) had at baseline higher baseline uric acid levels (5.6±1.9 vs. 4.7±1.3mg/dL, P=0.01), left ventricular mass index (LVMI) (118.2±25.8 vs. 101.6±26.3g/m2, P=0.01) and prevalence of LV hypertrophy (49.2% vs. 26.6%, P=0.01) whereas no difference was observed with respect to baseline office BP, renal function and lipid levels. In multivariate Cox regression model baseline glomerular filtration rate (HR=1.02, P=0.01) LVMI (HR=1.01, P=0.02) and uric acid (HR=1.25, P=0.02) turned out to be independent predictors of CAD.
Conclusions |
In EH patients uric acid predicts future development of CAD. These findings further support that uric acid estimation could improve overall risk stratification in EH. These results may help us to understand the underlying process of increased cardiovascular risk in women with high uric acid.
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Vol 10 - N° 1
P. 108-109 - janvier 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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