Increased transforming growth factor-ß associated with hypertrophic cardiomyopathy: Prognostic marker - 05/01/18
Résumé |
Background |
Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease characterized by myocardial fibrosis. Several major cytokines are identified to contribute fibrotic responses. Transforming growth factor beta (TGF-ß) is one of the major profibrotic cytokines which is implicated in cardiac fibrosis.
Purpose |
We sought to explore changes in TGF-ß levels between patients with HCM and non HCM and to test if his higher levels may be related to poor prognosis in HCM.
Methods |
A total of 31 patients with HCM and 39 non HCM were enrolled. enzyme linked immuno sorbent assay (ELISA) was used to measure serum levels of TGF-ß, amino terminal propeptide of type III procollagen (PIIINP) and plasma levels of matrix metalloproteinase (MMP)-3 and tissue inhibitor (TIMP)-2. We used the receiver operating characteristic (ROC) curve analysis to find a cutoff value. The 95% confidence interval (CI) was also calculated for sensitivity and specificity.
Results |
Serum TGF-ß levels were significantly higher in HCM patients than in non-HCM subjects (123.56±72.58 versus 38.88±21.10pg/mL; P<0.001). Plasma levels of TIMP-2 were lower (59.88±31.18 versus 100.53±57.49ng/mL; P=0.001). PIIINP was correlated positively with maximal wall thickness (r=0.622; P<0.001), intraventricular septum thickness (r=0.481; P=0.006) and left ventricular (LV) mass indexed (r=0.777; P<0.001). TGF-ß levels of >57.86pg/mL can predict adverse events with a specificity of 84% and a sensitivity of 86% [area under curve (AUC): 0.906, 95% CI: 0.825–0.988, P=0.04].
Conclusion |
The higher levels of TGF-ß in this present study suggest that TGF-ß could be a prognostic marker in HCM.
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Vol 10 - N° 1
P. 37 - janvier 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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