Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts (“Lifebrain”) - 28/02/18

Doi : 10.1016/j.eurpsy.2017.12.006

Kristine B. Walhovd ^a , Anders M. Fjell ^a, René Westerhausen ^a, Lars Nyberg ^b , Klaus P. Ebmeier ^c,^⁎ , Ulman Lindenberger ^d , David Bartrés-Faz ^e , William F.C. Baaré ^f , Hartwig R. Siebner ^f, Richard Henson ^g , Christian A. Drevon ^h , Gun Peggy Strømstad Knudsen ⁱ , Isabelle Budin Ljøsne ⁱ, Brenda W.J.H. Penninx ^j , Paolo Ghisletta ^k,^l , Ole Rogeberg ^m , Lorraine Tyler ⁿ , Lars Bertram ^o
Lifebrain Consortium^¹
See 4. Lifebrain Consortium.
^a University of Oslo Centre for Lifespan Changes in Brain and Cognition (UiO), Department of Psychology, Harald Schelderups Hus, Forskningsveien 3A, N-0373 Oslo, Norway
^b Centre for Functional Brain Imaging (Umeå), Umeå Universitet, SE-90187, Umeå, Sweden
^c University of Oxford Wellcome Centre for Integrative Neuroimaging & Department of Psychiatry (UOXF), University of Oxford, Warneford Hospital, Oxford OX37JX, UK
^d Max-Planck Institute for Human Development Centre for Lifespan Psychology (MPIB), Lentzeallee 94, D-14195 Berlin, Germany
^e University of Barcelona Brain Stimulation Lab (UB), Facultat de Medicina, Campus Clínic, C/. Casanova, 143, Ala Nord, 5a planta, S-08036, Barcelona, Spain
^f Region Hovedstaden (RegionH), Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Section 714, Kettegard Allé 30, DK-2650, Hvidovre, Denmark
^g Medical Research Council Cognition and Brain Science Unit (MRC), University of Cambridge,15 Chaucer Road, Cambridge, CB2 7EF, UK
^h Vitas AS (Analytical Services), Gaustadalléen 21, N-0349 Oslo, Norway
ⁱ Norwegian Institute of Public Health Oslo (NIPH), PO Box 4404 Nydalen, N-0403 Oslo, Norway
^j VU University Medical Centre (VUmc), PO Box 7057, NL-1007 MB Amsterdam, The Netherlands
^k University of Geneva (UNIGE), Faculty of Psychology and Educational Sciences, Research group of Methodology and Data Analysis, Sandrine Amstutz, Uni Mail, 4e étage, Bd du Pont-d'Arve 40, 1205 Genève, Switzerland
^l Swiss Distance Learning University, Brig, Switzerland
^m Ragnar Frisch Centre for Economic Research (Frisch), Gaustadalleen 21, N-0349 Oslo, Norway
ⁿ University of Cambridge Department of Psychology (UCAM), Downing Street, Cambridge CB2 3EB, UK
^o University of Lübeck Interdisciplinary Platform for Genome Analytics (LIGA-UzL), University of Lübeck, Maria-Goeppert-Str. 1 (MFC1), 23562 D-Lübeck, Germany

^⁎Corresponding author.

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Wednesday 28 February 2018
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Abstract

The main objective of “Lifebrain” is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total. By linking these data to other databases and biobanks, including birth registries, national and regional archives, and by enriching them with a new online data collection and novel measures, we will address the risk factors and protective factors of BCM health. We will identify pathways through which risk and protective factors work and their moderators. Exploiting existing European infrastructures and initiatives, we hope to make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on BCM health maintenance, as well as the onset and course of BCM disorders. This will lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of BCM health, and translate into future preventive and therapeutic strategies. Aiming to improve clinical practice and public health we will work with stakeholders and health authorities, and thus provide the evidence base for prevention and intervention.

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Keywords : Psychiatric disorder, Dementia, Economics and psychiatry, Epidemiology, MRI, Neurodevelopment