Performance of spleen stiffness measurement in prediction of clinical significant portal hypertension: A meta-analysis - 01/06/18
pages | 11 |
Iconographies | 6 |
Vidéos | 0 |
Autres | 0 |
Highlights |
• | Spleen stiffness measured by ultrasound-based elatography could predict the presence of clinical significant portal hypertension (HVPG≥10mmHg) with good sensitivity and specificity. |
• | Spleen stiffness was also appropriate for screen severe portal hypertension (HVPG≥12mmHg). |
• | HVPG is an important tool to assess portal hypertension and SS cannot replace HVPG yet. |
Summary |
Aim |
Our purpose was to evaluate the correlation between spleen stiffness (SS) measured by ultrasound-based elastography and hepatic venous pressure gradient (HVPG) and assess the accuracy of SS in detecting clinical significant portal hypertension (CSPH) and severe portal hypertension.
Method |
Nine studies were included from thorough literature research and selection processes. A random model was used to analyze the correlation between HVPG and SS. We adopted the bivariate mixed effects model to assess the diagnostic performance.
Results |
Regarding to correlation between SS and HVPG, the summary correlation coefficient was 0.72 (95% confidence interval [CI], 0.63–0.80). In detection of CSPH, the sensitivity, specificity, AUC and DOR were: 0.88 (0.70–0.96), 0.84 (0.72–0.92), 0.92 (0.89–0.94) and 38 (17–84) for CSPH, respectively; and 0.92 (0.82–0.96), 0.79 (0.72–0.85), 0.87 (0.84–0.90) and 41 (17–100) for severe portal hypertension, respectively.
Conclusion |
Correlation between SS and HVPG was good. Although SS showed good sensitivity and specificity, the different cut-off values and techniques among studies might limit the impact of our results on clinical practice. Therefore, more high-quality prospective studies are required to evaluate the role of SS in predicting portal hypertension.
Le texte complet de cet article est disponible en PDF.Keywords : Spleen stiffness, Elastography, Portal hypertension, Chronic liver disease, Correlation coefficient
Plan
Vol 42 - N° 3
P. 216-226 - juin 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?