Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus - 11/07/18
, Hongwei Liu a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | The immunomodulatory function of OLP-MSCs is impaired compared with N-MSCs. |
• | TGP partially improved OLP-MSCs immunomodulatory function via miR-124/STAT3 pathway. |
• | TGP may be a new and safe drug for priming mesenchymal stem cells. |
Abstract |
Mesenchymal stem cells (MSCs) have been used clinically and experimentally to relieve severe immune-related diseases due to their immunomodulatory properties, but these are impaired by inflammation. Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucosal disease. In the present study, we found MSCs from OLP with higher expression of interleukin (IL)-6, tumour necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β) and IL-10 compared with control. Total glucosides of paeony (TGP) significantly improves the immunomodulatory function of MSCs by inhibiting IL-6 and TNF-α expression and increasing TGF-β and IL-10 expression. Moreover, TGP can downregulate p-STAT3 expression through upregulation of miR-124. The changes of IL-6, TGF-β and p-STAT3 were further confirmed by overexpression and knockdown of miR-124 in MSCs. Taken together, the immune-regulating function of MSCs can be improved by TGP via the miR-124/STAT3 pathway.
Le texte complet de cet article est disponible en PDF.Keywords : Mesenchymal stem cells, Oral lichen planus, Total glucosides of paeony, miR-124, STAT3
Plan
Vol 105
P. 151-158 - septembre 2018 Retour au numéro
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