Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats - 11/07/18
, Lucas Casagrande , Jorge Felipe Argenta Model , Jordana Tres dos Santos , Ana Lúcia Hoefel , Luiz Carlos Kucharski Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | Yerba Mate decreased retroperitoneal adipose tissue in healthy rats. |
• | Yerba Mate improved diabetic serum glucose, creatinine, urea and total protein. |
• | Yerba Mate improved muscle weight and metabolic parameters in diabetic rats. |
Abstract |
The relationship between metabolic disturbances and clinical events related to diabetes is well known. Yerba mate has presented a potential use as preventive and therapeutic agent on diabetes. The aim of this study was to evaluate the effect of yerba mate on different tissues of diabetic rats, focusing on energetic metabolism. Diabetes was induced by streptozotocin, followed by daily yerba mate treatment. After 30 days, the animals were euthanized to evaluate metabolic parameters on liver, adipose tissue, muscle and serum. The results showed mate treatment promoted a decrease in retroperitoneal adipose tissue in healthy animals. Muscle weight returned to control levels in diabetic rats treated with mate. There was improvement on serum glucose, creatinine, urea and total protein levels associated with mate treatment. Muscle parameters, such as glucose uptake and carbon dioxide production, were improved by mate treatment to control levels. The results evidenced the beneficial actions mate can have on metabolic disturbances of diabetes.
Le texte complet de cet article est disponible en PDF.Abbreviations : C group, CM group, D group, DM group, STZ, RAT, EAT, SM, L, 14C, KRB, [U-14C]-glucose, [14C-2-DG], GLP-1, PEPCK, ApoA-I, AST, ALT, HMG-CoA, GLUT
Keywords : Diabetes, Ilex paraguariensis, Liver, Metabolism, Muscle
Plan
Vol 105
P. 370-376 - septembre 2018 Retour au numéro
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