Biogenic gold nanoparticles synthesis mediated by Mangifera indica seed aqueous extracts exhibits antibacterial, anticancer and anti-angiogenic properties - 11/07/18
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Graphical abstract |
Highlights |
• | Biogenic gold nanoparticles were synthesized using Mangifera indica seed extract. |
• | AuNP’s were biologically safe and detrimental to human gastric cancer cells. |
• | It reduced the growth of both gram positive and gram negative strains. |
• | It inhibited angiogenesis by targeting Ang-1/Tie2 pathway in CAM model. |
Abstract |
During the last few decades, gold nanoparticles (AuNP’s) have gained considerable attention in nanomedicine and expanded its application in clinical diagnosis and as therapeutics. Employing plant extract for synthesising gold nanoparticles proves to be an eco-friendly technology for large scale production. It is highly economical and suitable for biological applications by negating the use of chemicals involved in conventional route. In this study, AuNP’s was prepared by a simple one step method of employing aqueous Mangifera indica seed extract as a reducing agent. Scanning electron microscopy and transmission electron microscopy revealed spherical shaped nanoparticles and dynamic light scattering analysis indicated the AuNP’s to be approximately 46.8 nm in size. AuNP’s efficiently inhibited the growth of E. coli and S. aureus by its inherent ability to generate reactive oxygen species (ROS) and exhibited detrimental effects towards the tested bacterial species. Biocompatibility assessment indicated the non-toxic nature of AuNP’s towards mesenchymal stem cells at 25 μg/ml and interestingly, suppressed the growth of human gastric cancer cells under in vitro culture conditions. AuNP’s significantly exhibited anti-angiogenic property in chick chorioallantoic membrane model (CAM) by downregulating Ang-1/Tie2 pathway. Overall, the synthesized AuNP’s exhibited antibacterial and anti-angiogenic properties with high biocompatibility thereby supporting its candidature for various biomedical applications. It can be employed in suppressing tumor growth, combat inflammatory diseases that necessitate the involvement of angiogenesis suppression, and antibacterial activity is suitable for its clinical translation to negate surgery associated infections.
Le texte complet de cet article est disponible en PDF.Keywords : Gold nanoparticles, Anti-bacterial activity, Biocompatible, Anti-angiogenic property, CAM assay
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Vol 105
P. 440-448 - septembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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