Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation - 11/07/18
, Klára Szentmihályi a , Gergő Szabó b , Dénes Kleiner b , Imre Varga c , Anna Egresi b , Zoltán May a , Péter Nyirády d , Miklós Mohai e , Anna Blázovics b Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 8 |
| Iconographies | 1 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
*significant difference to the patient control (A) p < 0.01.
**significant difference to the high risk prostate cancer without vitamin D3 treatment (C) p<0.01.
Abbreviations: A, patient control; B, patient control with vitamin D3 treatment; C, high-risk prostate cancer group; D, high-risk prostate cancer group with vitamin D3 treatment; E, vitamin D3 treated cancerous group with androgen deprivation therapy.
Highlights |
• | Vitamin D3 treatment was applied for patient controls and prostate cancerous patients with different states. |
• | Vitamin D3 treatment had an effect on PSA level. |
• | Vitamin D3 treatment helped to equilibrate the redox homeostasis. |
• | Vitamin D3 treatment influenced on the metal element homeostasis, especially in the cases of Ca, Cr, Cu, Fe, Li and Pb. |
Abstract |
Vitamin D3 supplementation has a beneficial effect on cancerous patients, although it can influence the redox- and metal homeostasis. The aim of our investigation was to demonstrate the effect of vitamin D3 consumption on the redox- and metal homeostasis in prostate cancer, because of the recommended daily dose increased from 200 IU to 2000 IU in recent years in Hungary. Forty-three volunteers were involved in the study. The grouping was applied according to the clinical routine laboratory parameters (vitamin D3) and the tumor markers (PSA, fPFA). Patients were divided into 5 groups: (A) patient control (N = 8), (B) patient control with vitamin D3 treatment (N = 9), (C) high-risk prostate cancer group (N = 6), (D) high-risk prostate cancer group with vitamin D3 treatment (N = 8) and (E) vitamin D3 treated cancerous group with androgen deprivation therapy (N = 11). The element concentrations were determined with ICP-OES. Among the redox parameters, free radical scavenging capacity and H-donating ability were determined with luminometry and spectrometry. Vitamin D3 treatment caused differences in the metal- and redox homeostasis in either patient control and cancerous groups. The concentration of Fe, Cr, and Pb significantly increased in the erythrocytes of prostate cancer patients. According to the higher scavenging capacity by vitamin D3 treatment, it seems that vitamin D3 helps to equilibrate the redox homeostasis that could affect the outcome of cancer positively. However, the tendency in the metal element status does not give a clear explanation of cancer's outcome, but the accumulation of Pb by vitamin D3 supplementation needs to be taken into more serious consideration in set terms of occupational diseases.
Le texte complet de cet article est disponible en PDF.Abbreviations : Al, ALT, AP-1, AR, AST, B, Ba, BMI, Ca, CDK4, CEA, Chol, CHR, CKI, Co, Cr, CREA, CRP, Cu, DNA, DV, EGF, Fe, fPSA, G1, G2, GADD45α, GGT, GOT, GPT, GSK-3, H2O2, HCHO, HCl, HGB, HIF-1, HNO3, ICP-OES, IKEB, IL-2, -6, -10, INK4, IU, LDH, Li, LMWCr, M, MCV, Mg, Mn, MV, NADH, NFAT, NF-κB, Ni, P, p21waf1, p27kip1, p53, Pb, PDGF, PSA, R, RLU, RNA, RXR, S, Sr, Ti, TNF-α, TSC, TUKEB, UA, V, VDR, VEGF, WBC, Zn
Keywords : Micro-macro elements, prostate cancer, vitamin D3, ICP-OES
Plan
Vol 105
P. 558-565 - septembre 2018 Retour au numéro
Article précédent
- Down-regulation of miR-214 inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2
- Kejian Zhang, Mingrui Zhang, Hui Jiang, Fenglin Liu, Hongwei Liu, Yang Li
- ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment
- Li Pan, Hongli Yang, Cong Xu, Shuangfeng Chen, Zhen Meng, Keyi Li, Haiying Chen
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?