Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats - 11/07/18
, Evandro José Beraldi b , Stephanie Carvalho Borges b , Maria Raquel Marçal Natali b , Nilza Cristina Buttow b Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 10 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Nitrosative and oxidative stress is cause of the damages to the myenteric plexus. |
• | RSV presented antioxidant effect in the intestinal wall in diabetic rats. |
• | RSV promoted neuroprotection in the myenteric plexus in diabetic rats. |
• | RSV may be promising for the treatment of damage in the ENS caused by diabetic. |
Abstract |
Damages to the enteric nervous system caused by diabetes mellitus (DM) are frequently attributed to oxidative and nitrosative stress. We aimed to investigate the effect of Resveratrol (RSV) (10 mg/kg) on oxidative and nitrosative stress in the intestinal wall and morphoquantitative aspects of the myenteric plexus of the duodenum, jejunum and ileum in diabetic rats. Twenty-four rats were distributed into four groups (n = 6/group): control (C group), control treated with RSV (CR group), diabetic (D group), and diabetic treated with RSV (DR group) for 120 days. Immunohistochemical staining techniques for the general neuronal population, nitrergic and calretinin neuronal subpopulations, enteric glial cells and glial fibrillary acid protein were performed in the myenteric plexus. Furthermore, parameters of oxidative and nitrosative stress were analyzed in the intestinal wall. RSV attenuated oxidative and nitrosative stress and prevented neuronal loss and hypertrophy of the HuC/D-IR, nNOS-IR and CALR-IR neuronal subpopulations in the DR group compared with the D group (P < 0.05). In addition, RSV prevented the increase in glial fibrillary acid protein fluorescence in the DR group compared with the D (P < 0.05). These results suggest that RSV has antioxidant and neuroprotective effects in myenteric plexus in rats with experimental DM.
Le texte complet de cet article est disponible en PDF.Keywords : Resveratrol, Neuroprotection, Myenteric plexus, Diabetes, Oxidative stress, Nitrosative stress
Abbreviations : DAN, ENS, DM, RSV, STZ, GFAP, HuC/D, nNOS, CALR, S100, GSH, LOOH, SOD, GST, MPO, GB, TP, TG, TC, HDL, LDL, AST, ALT
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Vol 105
P. 724-733 - septembre 2018 Retour au numéro
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