Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats - 11/07/18
, Chang Qi b, Shasha Wang aBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 8 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Glucosamine plus vitamin E supplementation reduced lipid peroxidation. |
• | Glucosamine plus vitamin E increased antioxidant enzyme activity. |
• | Glucosamine plus vitamin E increased reduced glutathione and zinc levels. |
• | Glucosamine plus vitamin E reduced NF-κB, and iNOS protein expression. |
• | Glucosamine plus vitamin E exerted a synergistic effect against RA. |
Abstract |
The effect of glucosamine and vitamin E against rheumatoid arthritis (RA) in a neonatal rat model was investigated. Lipid peroxidation, superoxide dismutase (SOD), catalase, reduced glutathione (GSH), glutathione peroxidase (Gpx), matrix metalloproteinase-3 (MMP-3), prostaglandin E2 (PGE2), ceruloplasmin, copper, zinc, nitric oxide (NO), uric acid, inducible nitric oxide synthase (iNOS), and nuclear factor-kappaB (NF-κB) levels were determined in control and rheumatoid arthritis neonatal rats. Glucosamine plus vitamin E supplementation reduced the MDA level by 61.9% and increased the SOD, catalase, GSH, Gpx, and zinc levels. MMP-3, PGE2, ceruloplasmin, copper, NO and uric acid levels were significantly reduced by supplementation of glucosamine plus vitamin E. NF-κB, and iNOS protein levels were decreased by 47.7% and 39.5%, respectively, by glucosamine plus vitamin E supplementation. Thus, supplementation with glucosamine plus vitamin E exerted a synergistic effect against RA.
Le texte complet de cet article est disponible en PDF.Abbreviations : SOD, GSH, Gpx, MMP-3, PGE2, NO, iNOS, IL-1, TNF-α, MDA, TBARS, ELISA, SDS-PAGE, PVDF, ECL, SEM, ANOVA
Keywords : Glucosamine, Neonatal rats, Rheumatoid arthritis, Synergistic effect, Vitamin E
Plan
Vol 105
P. 835-840 - septembre 2018 Retour au numéro
Article précédent
- Potent tocolytic activity of ethyl acetate fraction of Ananas comosus on rat and human uteri
- Faezeh Monji, Lang Chu Lau, Abrar Al-Mahmood Siddiquee, Baharudin Bin Said, Lay-Kien Yang, Yoganathan K., Mahesh A. Choolani, P. Ganesan Adaikan
- Suppression of SMOC2 reduces bleomycin (BLM)-induced pulmonary fibrosis by inhibition of TGF-β1/SMADs pathway
- Li Luo, Chang-Cheng Wang, Xiao-Ping Song, Hong-Mei Wang, Hui Zhou, Ying Sun, Xiao-Kun Wang, Shuo Hou, Fu-Yang Pei
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?