Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches - 20/09/18
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Highlights |
• | Tuberculosis (caused by Mycobacterium tuberculosis) treatment involves multiple drug regimens for prolonged periods. |
• | There are various limitations associated with the available multiple drug regimens prescribed for tuberculosis. |
• | Oxidative stress adversely influences the various treatment regimens in tuberculosis by driving cell death and apoptosis. |
• | Various novel controlled-release nano-carrier drug delivery systems could potentially benefit tuberculosis management. |
Abstract |
Tuberculosis (caused by Mycobacterium tuberculosis, Mtb) treatment involves multiple drug regimens for a prolonged period. However, the therapeutic benefit is often limited by poor patient compliance, subsequently leading to treatment failure and development of antibiotic resistance. Notably, oxidative stress is a crucial underlying factor that adversely influences the various treatment regimens in tuberculosis. Little information is available with advanced drug delivery systems that could be effectively utilized, in particular, for targeting the oxidative stress in tuberculosis. Thus, this presents an opportunity to review the utility of various available, controlled-release drug delivery systems (e.g., microspheres, liposomes, niosomes, solid lipid nanoparticles, dendrimers) that could be beneficial in tuberculosis treatments. This will help the biological and formulation scientists to pave a new path in formulating a treatment regimen for multi-drug resistant Mtb.
Le texte complet de cet article est disponible en PDF.Keywords : Mycobacterium tuberculosis, Oxidative stress, Drug delivery, Controlled release
Plan
Vol 107
P. 1218-1229 - novembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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