Treatment with Trichilia catigua ethyl-acetate fraction improves healing and reduces oxidative stress in TNBS-induced colitis in rats - 20/09/18
, Maiara Morselli Coelho Barbosa b , Maísa Carla Fortunato a , Ciomar Aparecida Bersani Amado c , Jurandir Fernando Comar b , Renata Longhini d , João Carlos Palazzo de Mello d , Maria Raquel Marçal Natali a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | Chemically-induced colitis causes colonic damage, increasing oxidative stress in the blood. |
• | A single oral dose of Trichilia catigua extract reduces oxidative stress markers. |
• | Trichilia catigua extract improves wound healing, reducing colonic damage. |
• | Oral administration of the extract is more efficacious than an enema. |
Abstract |
Beverages containing Trichilia catigua are commonly employed in folk medicine. T. catigua bark extracts possess antioxidant, anti-inflammatory, and bactericidal properties. These properties suggest T. catigua bark extracts as a potential treatment for inflammatory bowel diseases (IBD). Using the 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced model of colitis in rats we evaluated the effect of an ethyl-acetate fraction (EAF) of T. catigua (200 mg/kg) administered by daily oral gavage or intrarectally at different time points after TNBS challenge. TNBS treatment evoked severe colonic inflammation after 24 h that persisted for 7 days, characterized by weight loss, high levels of myeloperoxidase activity, histological and macroscopic damage, and elevated index of oxidative stress in the blood. T. catigua EAF treatment prevented the oxidative stress within 24 h and enhanced tissue recovery observed at day 7, returning histological and macroscopic damage levels to that of the control group. TNBS treatment led to loss of myenteric neurons after 28 days. T. catigua EAF was unable to prevent the neuronal loss. Oral delivery of T. catigua EAF was more effective than intrarectal administration of the extract. In conclusion, T. catigua EAF treatment normalized oxidative stress parameters in blood and reduced the degree of acute inflammation in TNBS colitis.
Le texte complet de cet article est disponible en PDF.Abbreviations : EAF, IBD, MPO, TNBS
Keywords : Colon, Inflammatory bowel disease, Myenteric neurons, TNBS, Trichilia catigua, Ethyl-Acetate fraction
Plan
Vol 107
P. 194-202 - novembre 2018 Retour au numéro
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