Anti-exercise-fatigue and promotion of sexual interest activity of total flavonoids from wasps drone-pupae in male mice - 20/09/18
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Highlights |
• | The total flavonoids in wasp drone pupae were extracted by response surface methodology for the first time. |
• | The activity of total flavonoids of drone pupae to exercise fatigue was found. |
• | The effect of total flavonoids from drone pupae on sexual interest of male mice under fatigue condition was evaluated. |
• | The results provide suggestions for the application of total flavonoids in the wasps drone pupae. |
Abstract |
The aim of this research was to evaluate the anti-exercise-fatigue and promotion of sexual interest of total flavonoids from drone pupae of wasps. DPTF was prepared by ethanol extracting and its extraction conditions were optimized by response surface methodology. Then, anti-exercise-fatigue and promotion of sexual interest of DPTF were evaluated. The optimums extraction conditions by RSM were ethanol concentration 65%, extraction time 3 h and solid-to-liquid 20:1(mL/g). No mortality and general symptoms of toxicity were observed in the DPTF treated mice(1 g/kg,3 g/kg,5 g/kg body weight) the body weight and food consumption were not significantly changed compared with the normal control group. The relative weights of main organ did not markedly change. DPTF can significantly extend the duration of the swimming time to exhaustion and the times of capture the female in mice, decrease BUN, LAC and Cr levels, increase LG, GG and T activities in the DPTF treated mice. The dose of 5 g/kg body weight is the optimal dose for anti-exercise-fatigue activity and promotion of sexual interest in male mice. In conclusion, DPTF is promising traditional natural-based therapeutic remedy for relieving exercise-fatigue with high safety.
Le texte complet de cet article est disponible en PDF.Abbreviations : DPTF, BUN, LA, LG, Cr, GG, T, FCT, CTS
Keywords : Drone pupae total flavonoids, Anti-fatigue, Promotion of sexual interest, Response surface methodology
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Vol 107
P. 254-261 - novembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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