Asiaticoside counteracts the in vitro activation of microglia and astrocytes: Innuendo for multiple sclerosis - 20/09/18
pages | 3 |
Iconographies | 2 |
Vidéos | 0 |
Autres | 0 |
Abstract |
Background |
During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage.
Purpose |
In this study, we have explored the action of Asiaticoside A against the activated microglia and astrocytes.
Methods |
Primary microglia and astrocyte cultures were used for the study and the activity were evaluated using cell proliferation assay, nitrate assay and TNFα estimation using ELISA.
Results |
Asiaticoside A inhibited the production of nitric oxide and TNFα in LPS activated primary microglia and astrocyte cultures.
Conclusion |
This study suggests that Asiaticoside A may be effective against the progression of MS.
Le texte complet de cet article est disponible en PDF.Abbreviations : MS, CNS, LPS, TNFα, PDL
Keywords : Asiaticoside, Microglia, Astrocyte, Multiple Sclerosis, Primary cell culture
Plan
Vol 107
P. 303-305 - novembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?