Identification of N-Hydroxycinnamamide analogues and their bio-evaluation against breast cancer cell lines - 20/09/18
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Graphical abstract |
Highlights |
• | A series of N-hydroxycinnamamide derivatives were designed and synthesized. |
• | The synthesized compounds were screened against various breast cancer cell lines using MTT assay. |
• | The compound numbers 3b and 3h exhibit most potent activity with IC50 13μM and 5μM respectively. |
• | Compound 3h act via ROS production and promotes DNA fragmentation induction of apoptosis. |
Abstract |
The present study demonstrates the identification of N-hydroxycinnamamide derivatives and their anticancer potential against human triple-negative breast cancer cell line MDA-MB‑231, MCF-7 and non-malignant origin cell line, HEK-293 (human embryonic kidney). MTT assay was studied with HEK-293 cell line. Anticancer potential of the N-hydroxycinnamamide derivatives were compared with marked drug Tamoxifen through in vitro study. The compound numbers 3b and 3h exhibit most potent activity against antagonistic breast cancer cells (MDA-MB-231) with IC50 13μM and 5μM respectively. Compound 3h promotes DNA fragmentation and induction of apoptosis. Furthermore, loss of mitochondrial membrane potential induced by compound 3h. The major mechanism of compound 3h for anti-breast cancer activity was probably initiation of reactive oxygen species (ROS) in cancer cells thereby persuading apoptotic cell deaths in cancer cells.
Le texte complet de cet article est disponible en PDF.Keywords : Breast cancer, MDA-MB-231, MCF-7, N-Hydroxycinnamamide, HEK-293
Plan
Vol 107
P. 475-483 - novembre 2018 Retour au numéro
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