Premna integrifolia ameliorates cyclophosphamide-induced hepatotoxicity by modulation of oxidative stress and apoptosis - 20/09/18
, Sunil Kumar Mishra c, Vijay Kumar bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | The study investigates the ameliorative effect of EAEPI on CP-induced hepatotoxicity. |
• | Oral administration of EAEPI restored the blood cell count and liver functions. |
• | EAEPI inhibited the oxidative stress and damage in CP-intoxicated mice liver. |
• | Treatment of EAEPI attenuated the apoptotic cell death in the CP-intoxicated mice liver. |
Abstract |
The present study was designed to evaluate the ameliorative effect of ethyl acetate extract of Premna integrifolia L. (EAEPI) leaves in cyclophosphamide (CP)-induced hepatic injury in mice. Mice were intoxicated with CP (200 mg/kg b. wt., i.p.) for 5 weeks or EAEPI (400 and 600 mg/kg b. wt., orally) in combination with CP. The results demonstrated that EAEPI exerts protective effect against CP induced hepatotoxicity, as evident from restoration of altered haematological parameters and alleviations of liver marker enzymes in serum. EAEPI also attenuated oxidative stress and antioxidant markers as evident from reversal of lipid peroxidation, glutathione levels as well as activities of catalase and superoxide dismutase enzymes. Moreover, EAEPI attenuated apoptosis and histopathological liver tissue damage in CP-intoxicated mice. In conclusion, EAEPI could protect mice liver against cyclophosphamide toxicity by inhibiting oxidative stress and apoptosis.The protective activity of EAEPI may be due to presence of polyphenolic compounds as identified by UHPLC–Q-TOF-MS/MS.
Le texte complet de cet article est disponible en PDF.Abbreviations : CP, EAEPI, ROS, RBC, WBC, PL, Hb, PCV, AST, ALT, ALP, GSH, TBARS, MDA, SOD
Keywords : Cyclophosphamide, Premna integrifolia, Hepatotoxicity, Oxidative stress, Apoptosis
Plan
Vol 107
P. 634-643 - novembre 2018 Retour au numéro
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