Laser-Generated Au Nanoparticles for Bio-Medical Applications - 04/11/18
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Abstract |
Background |
The present study it is part of the study of the applications of biocompatible nanoparticles in a biological environment. Nowadays, in fact, nanoparticles are making it possible to reach surprising results in the field of biomaterials, drug delivery and their transport in the blood flux, as the use of the contrast medium for medical imaging and to be injected in tumors before to apply radio and thermal therapy. Nanoparticles modify the chemical and physical properties of solids, liquids, and gases and in particular of physiological liquids, soft and hard biological tissues.
Methods |
The present article focalizes on the role of Au nanoparticles for biological and medical applications in which their insertion in cells, tissues, and organs may improve the diagnostic imaging contrast with traditional X-ray imaging and the absorbed doses due to radio- and thermal-therapies. Their injection in the tissue, in fact, increases the effective atomic number of the tissue, thus the increment of the electron density of the medium causes higher radiation LET (linear energy transfer) with the increment of released dose and major effects of radiotherapy expositions.
Main findings |
The present paper shows the possibility to generate spherical gold nanoparticles with an average diameter of about 5 nm, pure and not agglomerated, biocompatible, stable and without the addition of chemical agents, by laser ablation of gold material in water. The solution can be directly injected in the extracellular liquid of cell cultures or directly in the blood flux of mice to be transported inside the complex living system. Here it is accumulated in specific organs in which the up-take and decay can be measured using suitable images of fluorescence of the organs of the mouse.
Conclusions |
The aim of this research is to transport the nanoparticles in places where tissue disease exists and reduce their concentration in healthy tissues. This permit a better observation of the diseased tissues and their preparation as targeting for radio- and thermal-therapy to be applied to damage tumor cells saving healthy tissues.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | Au-NPs, 5 nm in diameter, can be generated by Nd:Yag laser ablation in water. |
• | NPs modify the properties of solids, liquids, and gases, and biological tissues. |
• | Au-NPs can be used as contrast medium in X-ray diagnostic imaging. |
• | Au-NPs in biological tissues increase the absorbed dose during Radiotherapy. |
• | The localization of NPs only in the disease tissues is essential for therapy. |
Keywords : Au nanoparticles, Laser ablation, Medical imaging, Radiotherapy
Plan
Vol 39 - N° 5
P. 307-312 - novembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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