Assessment of different pre and intra-operative strategies to predict the actual ESMO risk group and to establish the appropriate indication of lymphadenectomy in endometrial cancer - 10/11/18
, Cyrille Huchon b, c, Foucauld Chamming's d, Marie-Aude Le Frère-Belda e, Laure Fournier d, f, Charlotte Ngô a, f, g, Fabrice Lécuru a, f, g, Anne-Sophie Bats a, f, gBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Purpose of investigation |
The objective of this study was to evaluate the best pre- and intra-operative strategy to determine the European Society for Medical Oncology (ESMO) risk group.
Materials and methods |
Retrospective study on patients supported for endometrial cancer between 2006 and 2011. Twelve algorithms, integrating endometrial biopsy for histological type and tumour grade, and ultrasound and/or magnetic resonance imaging (MRI)±intra-operative examination for determination of myometrial invasion, were built. The diagnostic values of each algorithm to predict high- and low-risk group were calculated.
Results |
During the study period, 159 patients were operated for endometrial cancer. On these 159 patients, 103 met the inclusion criteria. For the prediction of high-risk group, the best algorithm was endometrial biopsy and ultrasound, combined with MRI in case of myometrial invasion <50%±intra-operative examination in case of myometrial invasion <50% on MRI. For the prediction of low–risk group, the 2 best algorithms were endometrial biopsy and ultrasound or MRI, combined with MRI or ultrasound in case of myometrial invasion <50% and intra-operative examination in case of discrepancy between both exams. There was no internal or external validation.
Conclusion |
Our study suggests that the best strategy to predict actual ESMO risk group is endometrial biopsy and transvaginal ultrasound±MRI and intra-operative examination in case of myometrial invasion <50% on ultrasound.
Le texte complet de cet article est disponible en PDF.Keywords : Endometrial cancer, Lymphadenectomy, Ultrasound, MRI, Intra-operative examination
Plan
Vol 47 - N° 10
P. 517-523 - décembre 2018 Retour au numéro
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