Prevalence and distribution of HPV genotypes and cervical-associated lesions in sexually active young French women following HPV vaccine - 10/11/18
, V. Jooste b, c , D. Guenat d, e , D. Riethmuller d, f , A.M. Bouvier b, c , I. Bedgedjian a , J.L. Prétet d, e , S. Valmary-Degano a, d , C. Mougin d, e Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 0 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Background |
Despite the availability of safe and effective HPV vaccines in France, more than 80% of girls remain unvaccinated.
Setting |
A regional university hospital referral center in France.
Objective |
To estimate the overall prevalence and distribution of HPV in vaccinated, sexually active young French women who were screened for cervical cancer by cytology and HPV testing.
Methods |
High-risk HPV (HR-HPV) prevalence, genotype-specific prevalence and extent of multiple infections were assessed in 125 cervical samples from females with available vaccine data using hc2 assay and INNO-LiPA assay. HPV status was analyzed in accordance with cytological data.
Results |
In our series, mean age was 23 years, overall prevalence of HR-HPV was 52% and was correlated with the lesion grade. The diversity of HPV genotypes was broad. Single HR-HPV infections were identified in 11%, 21% and 47% of women with NILM, ASC-US/-H and LSIL respectively. Multiple infections with HR-HPV were detected in 28% of the specimens. Only 24.5% of women with NILM presented infections with 2 genotypes or more, vs 28% of women with ASC-US/-H and 35% of women with LSIL. The overall prevalence of genotypes covered by the quadrivalent vaccine was low (5.9%); with 4.2%, 0%, 0.8% and 0.8% for HPV 16, HPV 18, HPV 6 and HPV 11 respectively.
Conclusion |
Among HPV-vaccinated young women, HR-HPV are detected at a high rate, and an association with the grade of cytological abnormalities was observed. However, HPV 16 and 18, both targeted by the vaccines, are remarkably rare among young French women since program implementation.
Le texte complet de cet article est disponible en PDF.Keywords : Human papillomavirus, HPV vaccine, HPV prevalence, HPV 16, Prevention, Cervical cancer
Plan
Vol 47 - N° 10
P. 525-531 - décembre 2018 Retour au numéro
Article précédent
- Assessment of different pre and intra-operative strategies to predict the actual ESMO risk group and to establish the appropriate indication of lymphadenectomy in endometrial cancer
- Sarah Vieillefosse, Cyrille Huchon, Foucauld Chamming's, Marie-Aude Le Frère-Belda, Laure Fournier, Charlotte Ngô, Fabrice Lécuru, Anne-Sophie Bats
- Estrogen receptor, progesterone receptor and CD8+ expression in endometrium of women of unexplained infertility
- Shilpi Gupta Dixit, Surajit Ghatak, Pratibha Singh, Shilajit Bhattacharya
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?