Protective effect of syringaldehyde on biomolecular oxidation, inflammation and histopathological alterations in isoproterenol induced cardiotoxicity in rats - 13/11/18
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 9 |
| Iconographies | 10 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Myocardial infarction induced by isoproterenol in rats showed elevation in the level of cardiac marker enzymes and TNFα, IL 6, NO, MDA and protein carbonyl level. |
• | SYD pre-co-treatment alleviated the increased level of cardiac marker enzymes, TNF α,IL 6, NO and reduced the oxidation of lipids, proteins. In addition, SYD treatment decreased the infarct size while increased TAC, GSH level and activity of antioxidant enzymes. |
• | Furthermore, SYD treatment regulated membrane bound ATPases and alterations in RBCs structure and cardiac tissue architecture. |
• | Thus, SYD confer dose dependent cardio-protective activity. |
Abstract |
Background |
Ischemic injury during myocardial infarction (MI) is responsible for increased deaths among patients with cardiovascular disorders. Recently, research has been directed for finding treatment using natural compounds. This study was performed to investigate the effects of syrigaldehyde (SYD), a phytochemical against isoproterenol (ISO) induced cardiotoxicity model.
Methods |
For induction of MI, rats were intoxicated with two doses of ISO and were treated with SYD at three different concentrations (12.5, 25 & 50 mg/kg) both prior and simultaneous to ISO administration.
Results |
ISO group revealed amplified activity of marker enzymes (CKMB, LDH, AST, ALT), increased oxidation of proteins and lipid molecules. Moreover, augmentation in pro-inflammatory markers was also found. The same group also displayed marked changes in histopathology and erythrocyte (RBCs) morphology. SYD treated groups showed diminished levels of serum markers enzymes, lipid peroxidation and protein carbonyl (PC) with increment in antioxidant defense in cardiac tissues of ISO administered rats. Our findings also revealed the modulatory effect of SYD on membrane bound ATPases, showing that SYD significantly improved the ISO induced changes in membrane fluidity. Furthermore, decline in infarct size, alleviation of structural RBC damage and improved myocardial histopathological outcome were observed in treated groups. In addition, mitigation of biochemical and histopathological changes by SYD was found to be dependent on its concentration.
Conclusion |
SYD had cardioprotective efficacy owing to its antioxidative and anti-inflammatory properties. Our results support incorporation of SYD in regular diet for prevention of MI.
Le texte complet de cet article est disponible en PDF.Keywords : Syringaldehyde, Myocardial infarction, Proinflammatory cytokines, Oxidative stress, Cell morphology, Total antioxidant capacity
Plan
Vol 108
P. 625-633 - décembre 2018 Retour au numéro
Article précédent
- PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/β-catenin signaling pathway
- Sikang Gao, Junwu Hu, Xiongwen Wu, Zhihui Liang
- Protective effect of wax apple (Syzygium samarangense (Blume) Merr. & L.M. Perry) against streptozotocin-induced pancreatic ß-cell damage in diabetic rats
- Aree Khamchan, Tatdao Paseephol, Wanthanee Hanchang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?