01-5 - RELATION OF ELEVATED C REATIVE PROTEIN TO TRANSESOPHAGEAL ECHOCARDIOGRAPHICS FINDINGS IN NON VALVULAR ATRIAL FIBRILLATION. - 09/04/08
Diangelantonio [1],
Stéphane Ederhy [2],
Ghislaine Dufaitre [2],
Sandra Janower [2],
Catherine Meuleman [2],
Franck Boccara [2],
Joëlle Masliah [2],
Ariel Cohen [2]
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Background: Elevated levels of high-sensitivity C reactive protein (CRP) has not only been associated with the presence of atrial fibrillation (AF) but also could predict patients at increased risk for thrombo embolic events. However, the relation between inflammatory markers and the development of thromboembolic risk factors detected by transesophageal echocardiography (TEE) has not been yet fully characterized.
Objective: We investigated the relationship between CRP levels and TEE markers of thromboembolism.
Methods: The study group consisted of 146 non valvular atrial fibrillation patients (mean age 65.1 ± 14.7,70 male (47.8 %). Patients with a recent history of surgery (<3 months) or sepsis at the time of the admission were excluded from the present analysis. AF was considered to be secondary to a precipitating condition in 39 patients (acute coronary syndrome (n = 10), and congestive heart failure (n = 29)). AF was classified as paroxysmal (n = 63), persistent (n = 53) and permanent (n = 30). TEE parameters included left atrial (LA) area, LA appendage (LAA) emptying and filling velocities and presence of LA/LAA spontaneous echocardiographic contrast (SEC) and thrombus. Thrombogenic milieu was defined as the presence of any of the TEE findings.
Results: The table depicts the prevalence of LAA abnormalities according to CRP levels expressed in tertiles.
At multivariable analysis, adjusting for all variable associated with CRP levels, age (beta coefficient: 0.02 ; p = 0.03), acute coronary syndrome (beta: 1.38 ; p = 0.005) and presence of LA thrombogenic milieu (beta: 0.83 ; p = 0.002) were found independent predictors of CRP levels.
Conclusion: Our results suggest a link between LAA thrombogenic milieu and inflammation. Longitudinal studies are warranted to evaluate the prognostic impact of CRP levels on the risk of thrombo embolic clinical events.
© 2007 Elsevier Masson SAS. Tous droits réservés.
Vol 100 - N° 12
P. 1071 - décembre 2007 Retour au numéro
Article précédent
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- Trabelsi, Malek Akrout, Charfeddine Hanène, Krichène Salma, Maalej Abdelkader, Abid Leila, Hentati Mourad, Kammoun Samir
- 01-6 - THE ROLE OF TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN THE MONITORING OF ATRIAL FIBRILLATION ABLATION
- Echahidi Najmeddine, Jean Champagne, MD, François Philippon, MD, André St-Pierre, MD, Franck Molin, MD, Louis Blier, MD, Marcel Gilbert, MD, Jacques Villeneuve, MD, Dania Mohty, MD, Gilles O’ Hara, MD
Bienvenue sur EM-consulte, la référence des professionnels de santé.