Objectives: Although neurohormonal modifications in cystic fibrosis involve myocardial fibrosis, the possibility that left ventricular (LV) dysfunction may occur in adult patients with cystic fibrosis was poor explored. The aim of this stufy is to assess left ventricular systolic and diastolic function in adult patients with cystic fibrosis using 2D echocardiography and tissue Doppler imaging.
Materials and methods: We studied 17 adult patients with cystic fibrosis (mean age: 22,5 years ; 7 men) and compared them to 10 normal control subjects (mean age: 24,7 years ; 4 men). After 2D standard ultrasound examination, all patients underwent Tissue Velocity (TV) imaging and strain imaging in apical 4-chamber view with iE33. Philips® Q Lab prototype was used for data analysis.
Results: LV longitudinal strain and peak systolic TV on lateral wall are significantly lower in cystic fibrosis group (strain septal wall: p < 0.0001 ; strain lateral wall: p < 0,0002 ; S: p = 0,035). There is no significant difference among the groups concerning peak systolic TV on septal wall (S: p = 0,155) and peak diastolic TV (E septal wall: p = 0,302 ; E lateral wall: p = 0,536). Standard parameters of systolic and diastolic function do not differe significantly between two groups (LV ejection fraction: p = 0,221 ; E/Ea: p = 0,08 ; Am-Ap: p = 0,444).
Conclusion: Adult patients with cystic fibrosis may have impairment in regional systolic function detected by strain while ejection fraction remains normal.
© 2007 Elsevier Masson SAS. Tous droits réservés.