The interactions and biological pathways among metabolomics products of patients with coronary heart disease - 22/03/24
, Jun Yang b, ⁎, 2 Abstract |
Background |
Through bioinformatics analysis, this study explores the interactions and biological pathways involving metabolomic products in patients diagnosed with coronary heart disease (CHD).
Methods |
A comprehensive search for relevant studies focusing on metabolomics analysis in CHD patients was conducted across databases including CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, Nature, Web of Science, Springer, and Science Direct. Metabolites reported in the literature underwent statistical analysis and summarization, with the identification of differential metabolites. The pathways associated with these metabolites were examined using the Kyoto Encyclopedia of Genes and Genomes (KEGG). Molecular annotation of metabolites and their relationships with enzymes or transporters were elucidated through analysis with the Human Metabolome Database (HMDB). Visual representation of the properties related to these metabolites was achieved using Metabolomics Pathway Analysis (metPA).
Results |
A total of 13 literatures satisfying the criteria for enrollment were included. A total of 91 metabolites related to CHD were preliminarily screened, and 87 effective metabolites were obtained after the unrecognized metabolites were excluded. A total of 45 pathways were involved. Through the topology analysis (TPA) of pathways, their influence values were calculated, and 13 major metabolic pathways were selected. The pathways such as Phenylalanine, tyrosine, and tryptophan biosynthesis, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, and Glycine, serine, and threonine metabolism primarily involved the regulation of processes and metabolites related to inflammation, oxidative stress, one-carbon metabolism, energy metabolism, lipid metabolism, immune regulation, and nitric oxide expression.
Conclusion |
Multiple pathways, including Phenylalanine, tyrosine, and tryptophan biosynthesis, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, and Glycine, serine, and threonine metabolism, were involved in the occurrence of CHD. The occurrence of CHD is primarily associated with the regulation of processes and metabolites related to inflammation, oxidative stress, one-carbon metabolism, energy metabolism, lipid metabolism, immune regulation, and nitric oxide expression.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
A total of 87 metabolomics products were involved in 45 pathways in patients with CHD. The influence values of pathway TPA were calculated, and the results of 45 metabolic pathways involving 87 metabolites are illustrated. It can be observed that these metabolites primarily participate in the regulation of pathways such as Phenylalanine, tyrosine and tryptophan biosynthesis, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Glycine, serine and threonine metabolism, Biosynthesis of unsaturated fatty acids, Arginine and proline metabolism, Phenylalanine metabolism, Alanine, aspartate and glutamate metabolism, Glycerophospholipid metabolism, Linoleic acid metabolism, Arginine biosynthesis, Butanoate metabolism, Pyruvate metabolism, Glycolysis / Gluconeogenesis, Galactose metabolism, Neomycin, kanamycin and gentamicin biosynthesis, Arachidonic acid metabolism, Lipoic acid metabolism, Glutathione metabolism, and alpha-Linolenic acid metabolism, among others.
A total of 87 metabolomics products were involved in 45 pathways in patients with CHD. The influence values of pathway TPA were calculated, and the results of 45 metabolic pathways involving 87 metabolites are illustrated. It can be observed that these metabolites primarily participate in the regulation of pathways such as Phenylalanine, tyrosine and tryptophan biosynthesis, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Glycine, serine and threonine metabolism, Biosynthesis of unsaturated fatty acids, Arginine and proline metabolism, Phenylalanine metabolism, Alanine, aspartate and glutamate metabolism, Glycerophospholipid metabolism, Linoleic acid metabolism, Arginine biosynthesis, Butanoate metabolism, Pyruvate metabolism, Glycolysis / Gluconeogenesis, Galactose metabolism, Neomycin, kanamycin and gentamicin biosynthesis, Arachidonic acid metabolism, Lipoic acid metabolism, Glutathione metabolism, and alpha-Linolenic acid metabolism, among others.Le texte complet de cet article est disponible en PDF.
Highlights |
• | A total of 87 effective metabolites related to CHD were screened, involving 45 pathways. |
• | Effective metabolites involve processes and dicarboxylic acid metabolism pathways, and regulation of metabolites. |
• | The occurrence of coronary heart disease is mainly related to the processes and regulation of metabolites. |
Keywords : Bioinformatics, Coronary heart disease, Metabolomics, Metabolites interaction, Biological pathway analysis
Plan
Vol 173
Article 116305- avril 2024 Retour au numéro
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