P03-210 Conformation of albumin binding sites are disturbed in schizophrenia - 17/03/09
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Résumé |
Aim |
Investigate some properties of albumin binding sites in schizophrenic patients.
Methods |
Properties of serum albumin binding sites were studied using quenching of fluorescence of probe K-35 (N-carboxyphenylimide of dimethylaminonaphthalic acid) with nitrate anion. Serum samples were collected from 24 schizophrenic patients and 24 healthy volunteers.
Results |
In the absence of quencher specific probe fluorescence in patients was 1,4 times higher than in controls. Fluorescent quenching constant for probe bound to albumin was 2,5 L/mol in patients versus 4,6 L/mol in volunteers (p< 0,01). Fluorescent fraction assessable to quenching was significantly lower in patients than in volunteers. Fluorescent decay studies on S-60 synchrotron have revealed in patient’s albumin the redistribution between long-lived and short-lived molecules of the probe with increase of the latter. There were found decrease of albumin accessible SH-groups in schizophrenic patients as compared with volunteers.
Conclusions |
In schizophrenic patients conformational state of albumin binding sites is significantly disturbed that can lead to changes in protein-ligand interaction and to damage of main albumin functions (transport and detoxification) and aggravation of endotoxicosis.
Le texte complet de cet article est disponible en PDF.Vol 24 - N° S1
P. S1209 - 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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