Pulmonary manifestations of Sjögren’s syndrome

Sjögren’s syndrome is a chronic inflammatory disorder characterized by lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary glands. However, extraglandular organ systems may frequently be involved, including the lungs. Although subclinical pulmonary inflammation exists in more than 50% of patients, clinically significant pulmonary involvement affects approximately 10% of patients and may be the first manifestation of the disease. The entire respiratory tract may be involved, with a wide spectrum of manifestations including xerotrachea and bronchial sicca, obstructive small airway disease, various patterns of interstitial lung disease, lymphoinfiltrative or lymphoproliferative lung disease, such as lymphoma (usually of MALT type), pulmonary hypertension, pleural involvement, lung cysts, and pulmonary amyloidosis.

In this issue:

Quarterly Medical Review: Pulmonary Involvement in Systemic Disease s

Humbert M. (Clamart, France)

Lung involvement in systemic sclerosis

Hassoun PM. (Baltimore, USA)

Pleural and pulmonary involvement in systemic lupus erythematosus

Torre O. (Milan, Italy), et al.

The lung in rheumatoid arthritis

Amital A (Petach Tikva, Israel), et al.

Pulmonary manifestations of Sjögren’s syndrome

Hatron PY (Lille, France), et al.

Pulmonary veno-occlusive disease: the bête noire of pulmonary hypertension in connective tissue diseases?

O’Callaghan DS (Clamart, France), et al.