Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis - 08/03/11
Corresponding author. Tel.: +571 347 4570 ext. 270; fax: +571 349 9410.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 4 |
| Iconographies | 0 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objectives |
To determine factors influencing the age at onset of rheumatoid arthritis (RA).
Methods |
A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models.
Results |
Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor.
Conclusion |
Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Age, HLA-DRB1, TNF-308 A allele, Rheumatoid factor, Anti-CCP antibodies, Smoking
Plan
Vol 78 - N° 2
P. 175-178 - mars 2011 Retour au numéro
Article précédent
- Elderly onset of primary Sjögren’s syndrome: Clinical manifestations, serological features and oral/ocular diagnostic tests. Comparison with adult and young onset of the disease in a cohort of 336 Italian patients
- Costantino Botsios, Antonio Furlan, Pierantonio Ostuni, Paolo Sfriso, Marilisa Andretta, Francesca Ometto, Bernd Raffeiner, Silvano Todesco, Leonardo Punzi
- Traditional cardiovascular risk factors in rheumatoid arthritis: A meta-analysis
- Jean-Frédéric Boyer, Pierre-Antoine Gourraud, Alain Cantagrel, Jean-Luc Davignon, Arnaud Constantin
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?