Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern

Doi : 10.1016/j.eurpsy.2011.02.011

M. Delavest ^a, C. Even ^a ^b , N. Benjemaa ^a ^c, M.-F. Poirier ^a ^c, R. Jockers ^d, M.-O. Krebs ^a ^c

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 11 mai 2011
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Abstract

This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.

Keywords : Seasonal Affective Disorders, Mood disorders, Genetics