Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome - 13/08/11
Reprints: Steven S. Witkin, PhD, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 E 68 St., Box 35, New York, NY 10065Résumé |
Objective |
Patients with vulvar vestibulitis syndrome (VVS) and control subjects were tested for a polymorphism in the gene coding for the NALP3 component of inflammasomes, cytoplasmic structures regulating interleukin (IL)-1β production.
Study Design |
DNA from 143 women with VVS and 182 control women were tested for a length polymorphism in intron 4 of the gene (CIAS1) that codes for NALP3. Vestibular tissue was examined for NALP3 expression. Whole blood cultures were tested for Candida albicans-induced IL-1β production.
Results |
The allele 12 frequency was higher in control subjects than in the patients with VVS (P = .02). Among patients with VVS and a self-reported history of recurrent vulvovaginal candidiasis (RVVC), the allele 7 frequency was 43.9% as compared with 30.8% in patients with no history of RVVC and 26.9% in control women (P = .035 vs other patients and .001 vs control subjects). NALP3 was identified in vestibular tissue. C albicans-induced IL-1β production was reduced in samples from women with the 7,7 genotype (P = .030).
Conclusion |
Polymorphism in the CIAS1 gene may play a central role in the triggering of VVS in a subset of patients.
Le texte complet de cet article est disponible en PDF.Key words : CIAS1, genetic polymorphism, inflammasome, interleukin-1β, NALP3, recurrent vulvovaginal candidiasis, vulvar vestibulitis syndrome
Plan
| Cite this article as: Lev-Sagie A, Prus D, Linhares IM, et al. Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol 2009;200:303.e1-303.e6. |
Vol 200 - N° 3
P. 303.e1-303.e6 - mars 2009 Retour au numéro
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