Routine hepatitis C virus screening in pregnancy: A cost-effectiveness analysis - 18/08/11
Abstract |
Objective |
The purpose of this study was to determine whether routine hepatitis C virus screening in pregnancy is cost-effective.
Study design |
A decision tree with Markov analysis was developed to compare 3 approaches to asymptomatic hepatitis C virus infection in low-risk pregnant women: (1) no hepatitis C virus screening, (2) hepatitis C virus screening and subsequent treatment for progressive disease, and (3) hepatitis C virus screening, subsequent treatment for progressive disease, and elective cesarean delivery to avert perinatal transmission. Lifetime costs and quality-adjusted life years were evaluated for mother and child.
Results |
In our base case, hepatitis C virus screening and subsequent treatment of progressive disease was dominated (more costly and less effective) by no screening, with an incremental cost of $108 and a decreased incremental effectiveness of 0.00011 quality-adjusted life years. When compared with no screening, the marginal cost and effectiveness of screening, treatment, and cesarean delivery was $117 and 0.00010 quality-adjusted life years, respectively, which yields a cost-effectiveness ratio of $1,170,000 per quality-adjusted life year.
Conclusion |
The screening of asymptomatic pregnant women for hepatitis C virus infection is not cost-effective.
Le texte complet de cet article est disponible en PDF.Key words : Hepatitis C, Screening, Pregnancy, Cost-effective
Plan
| Supported by the Institute for Health Services Research and Policy Studies at Northwestern University and National Research Service Award 5 T32HS00078 from the Agency for Healthcare Research and Quality. Reprints not available from the authors. |
Vol 192 - N° 4
P. 1153-1161 - avril 2005 Retour au numéro
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