Cervical anti-inflammatory cytokine concentrations among first-trimester pregnant smokers - 18/08/11
Abstract |
Objective |
Anti-inflammatory cytokines play a role in the lower genital tract immune defense. We examined the impact of cigarette smoking in pregnancy on the detection of the 3 most important anti-inflammatory cytokines (interleukin-4, -10, and -13) in the cervix.
Study design |
One hundred fourteen gravid women from 4 to 16 weeks of gestation without bacterial vaginosis or sexually transmitted disease were queried regarding demographic factors and smoking. Concentrations of cytokines were determined with a multiplex assay for cervical swabs.
Results |
There was a positive linear relationship between the number of cigarettes that were smoked per day and cervical concentrations of interleukin-4, -10, and -13 (P < .001 for each). Median concentrations of interleukin-4 and -10 were greater among women who smoked ≥20 cigarettes per day than among non-smokers or less heavy smokers (P < .05 for both). There was no difference in concentrations of proinflammatory cytokines between smokers and non-smokers.
Conclusion |
Cigarette smoking in pregnancy is associated with an increase of cervical anti-inflammatory cytokines without a commensurate increase of proinflammatory cytokines. This may have important impact on the host response to infection.
Le texte complet de cet article est disponible en PDF.Key words : Smoking, Anti-inflammatory cytokine, Cervix, Pregnancy, Inflammation
Plan
Supported by National Institute of Child Health and Human Development grants 1 R01 HD41663-01A1 and MO1-RR000056. Presented in part at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology, San Diego, CA, August 5-7, 2004. Reprints not available from the authors. |
Vol 193 - N° 6
P. 1999-2003 - décembre 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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