Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata - 21/08/11
, Stacey A. Missmer, ScD a, b, c, Susan E. Hankinson, ScD a, c, Walter C. Willett, MD, DrPH a, c, d, Immaculata De Vivo, PhD a, c
Reprints: Dr Kathryn L. Terry, Obstetrics and Gynecology Epidemiology Center, 221 Longwood Ave, Boston, MA 02115Résumé |
Objective |
Carotenoids have antioxidant properties and have been associated with reduced risks of some cancers. We hypothesized that carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL).
Study Design |
We evaluated the associations between dietary carotenoids and risk of diagnosed UL in 82,512 premenopausal women aged 26-46 years in 1991 in the Nurses’ Health Study II over 10 years of follow-up. Diet was assessed every 4 years with a validated food frequency questionnaire, and incidence of UL was assessed biennially by questionnaire.
Results |
Total lycopene intake was not associated with diagnosed UL risk. Intake of beta-carotene was associated with slightly increased risks of diagnosed UL; this association was restricted to current smokers (for highest vs lowest quintile, relative risk = 1.36, 95% confidence interval 1.05 to 1.76; Ptrend = .003).
Conclusion |
Overall, our findings do not suggest that carotenoids reduce the risk of diagnosed UL. Among current smokers, high intake of beta-carotene may slightly increase risk of diagnosed UL.
Le texte complet de cet article est disponible en PDF.Key words : carotenoids, fibroids, uterine leiomyoma
Plan
| Cite this article as: Terry KL, Missmer SA, Hankinson SE, et al. Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata. Am J Obstet Gynecol 2008;198:37.e1-37.e8. This work was supported in part by DSM Nutritional Products Inc, Parsippany, NJ; National Cancer Institute Grants CA50385, CA67262, and T32 CA009001 (to K.L.T.); and American Cancer Society Research Scholar Grant RSG-00-061-04-CCE (to I.D.V.). |
Vol 198 - N° 1
P. null - janvier 2008 Retour au numéro
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