The timing of nutrient restriction during rat pregnancy/lactation alters metabolic syndrome phenotype - 22/08/11
, Dave Gayle, PhD, Jooby Babu, MD, Michael G. Ross, MD, MPH
Reprints: Mina Desai, PhD, Department of Obstetrics and Gynecology, LABioMed at Harbor-UCLA Medical Center, 1124 West Carson Street, Box 446, RB-1 Bldg, Torrance, CA 90502Résumé |
Objective |
Modulation of growth of intrauterine growth restricted (IUGR) newborns causes either adult obesity or normalization of body weight and fat. We investigated the impact of rapid versus delayed catch-up growth of IUGR offspring on glucose and lipid profiles.
Study Design |
From 10 days to term gestation and through lactation, control pregnant rats received ad libitum food, whereas study rats were 50% food restricted. Cross-fostering techniques were used to examine effects of food restriction during pregnancy and/or lactation periods. Glucose and lipid profiles were determined in offspring at ages 1 day, 3 weeks, and 9 months.
Results |
Food restriction during pregnancy produced hypoglycemic IUGR pups. Those permitted rapid catch-up growth demonstrated adult obesity with insulin resistance (hyperglycemia/hyperinsulinemia) and hypertriglyceridemia. Conversely, IUGR exhibiting delayed catch-up growth demonstrated normal adult body weight and insulin deficiency (hyperglycemia/hypoinsulinemia) and elevated cholesterol levels as compared with controls. However, these adult offspring had higher glucose though similar insulin levels as control offspring nursed by food restricted dam.
Conclusion |
The timing and the rate of IUGR newborn catch-up growth causes markedly altered adult phenotypes. Although delayed newborn catch-up growth may be beneficial in the prevention of adult obesity, there may be significant adverse effects on pancreatic function.
Le texte complet de cet article est disponible en PDF.Key Words : catch-up growth, glucose intolerance, intrauterine growth retardation, lipids, obesity
Plan
| Cite this article as: Desai M, Gayle D, Babu J, et al. The timing of nutrient restriction during rat pregnancy/lactation alters metabolic syndrome phenotype. Am J Obstet Gynecol 2007;196;555.e1-555.e7. This work was supported by National Institutes of Health Grant K01 DK 063994, American Heart Association Grant 0455117Y, and the March of Dimes Birth Defects Foundation. |
Vol 196 - N° 6
P. 555.e1-555.e7 - juin 2007 Retour au numéro
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