Maternal corticosteroid use and orofacial clefts - 22/08/11
, Gary M. Shaw, DrPH a, Chen Ma, MA a, Martha M. Werler, ScD, MPH b, Sonja A. Rasmussen, MD c, Edward J. Lammer, MD dNational Birth Defects Prevention Study
Reprints: Suzan L. Carmichael, PhD, March of Dimes Foundation, 5700 Martin Luther King Jr. Way, Oakland, CARésumé |
Objective |
The purpose of this study was to examine whether maternal corticosteroid use during pregnancy is associated with delivering an infant with an orofacial cleft.
Study Design |
This study included data on deliveries from the National Birth Defects Prevention Study, which is a population-based case-control study. Exposures were assessed by telephone interviews for mothers of 1141 cases with cleft lip ± cleft palate (CLP), 628 with cleft palate (CP), and 4143 controls.
Results |
Mothers of 33 infants with CLP (2.9%), mothers of 6 infants with CP (1.0%), and 72 control subjects (1.7%) reported corticosteroid use from 4 weeks before through 12 weeks after conception. The crude odds ratio for “any” vs “no” use was 1.7 (95% CI, 1.1-2.6) for CLP and 0.5 (0.2-1.3) for CP. When analyzed by route of administration and medication components, odds ratios for CLP tended to be elevated, and odds ratios for CP tended to be close to 1.
Conclusion |
Our results suggest a moderately increased risk of CLP among women who use corticosteroids during early pregnancy.
Le texte complet de cet article est disponible en PDF.Key words : corticosteroid, orofacial cleft
Plan
| The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. |
|
| Supported by a cooperative agreement from the Centers for Disease Control and Prevention, Centers of Excellence Award No.U50/CCU913241. |
|
| Cite this article as: Carmichael SL, Shaw GM, Ma C, et al. Maternal corticosteroid use and orofacial clefts. Am J Obstet Gynecol 2007;197:585.e1-585.e7. |
Vol 197 - N° 6
P. 585.e1-585.e7 - décembre 2007 Retour au numéro
Article précédent
- The effect of intrapartum penicillin on vaginal group B streptococcus colony counts
- Anna R. McNanley, J. Christopher Glantz, Dwight J. Hardy, David Vicino
- Placental sharing, birthweight discordance, and vascular anastomoses in monochorionic diamniotic twin placentas
- Liesbeth Lewi, Mieke Cannie, Isaac Blickstein, Jacques Jani, Agnes Huber, Kurt Hecher, Steven Dymarkowski, Eduard Gratacós, Paul Lewi, Jan Deprest
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?